Targeted locus amplification
The TLA technology uses the physical proximity of nucleotides within a locus of interest as the basis of selection. First, DNA is crosslinked, fragmented and religated. A primer pair complementary to a small locus-specific sequence is then used to amplify tens of thousands of surrounding base pairs. In this manner, the complete sequence of a locus is amplified. Amplified loci are subsequently sequenced with Next Generation Sequencing technologies. The TLA technology enables targeted complete sequencing of any locus or (trans) gene of interest and allows the detection of all single nucleotide variants (SNVs) and structural variants.
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