Tests on intestinal & hepatic human explants
The use of in vitro tests on isolated human cells and in vivo tests on animal models has limitations: the failure to take into account the tissue complexity for isolated cells and the failure to guarantee the possibility of extrapolating data obtained in animals to humans. For this reason, the use of human explants of stomach, intestine, skin or liver, provides a way to test the compounds on a complex human model closer to the physiological reality than isolated cells.
Several tests are available: viability, barrier function for intestinal explants, absorption and metabolism function, immune function, infection by pathogenic bacteria for skin and intestinal explants.
• Compounds or extracts to be tested
• Conditions of the test
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