Drug Discovery & Development
In vivo models
In vivo - target validation & efficacy
Target identification and validation characterizes the role of a protein or pathway of interest and provides selection arguments to define the required properties of the compounds to be screened. The main strategies involved in target validation are gene knock-out studies, knock-down by antisense RNA or RNA interference, and direct inhibition of proteins by small molecules, peptides, antibodies, aptamers, or any other class of inhibitors.
• Compounds to be tested
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