Single molecule visualization
The molecular combing technique is used on the genome to stretch individual DNA molecules to prepare them for hybridization. This allows direct visualization of DNA at the scale of the individual molecule. The molecular combing system simultaneously stretches and collects millions of DNA molecules on the surface of a glass lamella, the process applies to DNA molecule sizes exceeding the megabase. The technique is compatible with pre-labeled DNA and in situ hybridization. No amplification is required; therefore, no bias is introduced into the analysis.
• No amplification needed
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