Nuclear Magnetic Resonance (NMR) spectroscopy is used to study the structure of molecules, the interaction of various molecules, the kinetics or dynamics of molecules and the composition of mixtures.
In this experiment, small molecules will be analyzed by NMR, and the structure prediction of the molecules can be proposed.
Gas chromatography (GC) allows for the separation of a volatile mixture and injects the fractions in a mass spectrometry (MS) analyzer. MS will determine a unique spectra for each molecule, that will make possible the identification of this molecule by searching databases. A quantitative analysis is also possible using GC/MS.
Capillary electrophoresis (or CE) is a miniaturized analytical technique that has emerged since the late 1980s as an alternative to chromatographic techniques. It allows the separation of compounds of various kinds in capillaries most often fused silica under an electric field thanks to their differences of mobility.
La chromatographie en phase gazeuse (GC) permet de séparer les molécules d'un échantillon avant qu'elles ne soient analysées par un spectromètre de masse (MS). Les spectres obtenus, caractéristiques de chaque molécule, permettent une identification par recherche dans des bases de données. Une analyse quantitative est également possible par GC/MS.
The purpose of the determination of metals is to detect the presence of heavy metals in drugs, or in metal-based medical devices (quantum dots). It also allows the determination of metals in animals, or in in vitro samples for biodistribution studies. In this service the determination of metal can be done by inductively coupled plasma mass spectrometry (ICP-MS) or by atomic absorption spectrometry (AAS).
The peroxide value is used to characterize a vegetable oil, or an animal fat. This service allows the analysis of the peroxide index in samples such as oils, or solid fat.
Single Crystal Diffraction in single crystal (here diffraction of X-Ray, so method is called Single Crystal X-Ray Diffraction, SCXRD) is the most important and – if an appropriate sample (=single crystal) is available – also the fastest methodology currently available for the determination of the atomic structures of small molecules.
Knowledge of 3-D molecular structures allows e.g. description of intermolecular interactions or studying of changes of 3-D configuration of molecules crystallized under different chemical environment.
Nanoparticle Tracking Analysis (NTA) uses light diffusion to measure particle size (from 10 nm to 2000nm) in a liquid medium. Fluorescent particles can be monitored. This technique allows real-time monitoring of particle variation. NTA is used for the development of drug delivery systems, viral vaccines and nanoparticles.
The characterization of extracellular vesicles (EVs), such as exosomes, is performed by the Exoview in an automated manner. Because of their size, it is difficult to isolate exosomes. The use of Exoview makes it possible. It allows the characterization of these vesicles and the validation of their molecular content. Sample purification is not required.