Biobanks: collections of biological samples for endocrinal, metabolic and nutritional diseases

Biological samples from patients with endocrine and nutritional diseases

Biobanks (also known as biological resource centers) are entities responsible for the management of biological samples and their associated data.
These structures can collect and preserve biological samples from patients with endocrine, nutritional and metabolic diseases in the form of samples inventory.

Endocrine diseases are due to a dysfunction in hormone secretion from endocrine glands (thyroid, hypothalamus, pituitary gland, adrenal glands etc.). Nutritional diseases result from an exceeded or underrun dietary imbalance. Finally, metabolic diseases affect the metabolism of certain elements in humans such as carbohydrates, lipids, iron, calcium etc.
These imbalances and dysfunctions are at the origin of many pathologies such as diabetes, hypertension and obesity.

Samples from patients suffering from endocrine, metabolic or nutritional diseases come in a variety of forms: biological fluids (serum, plasma, urine, etc.), nucleic acid extractions (DNA and RNA) or cell cultures from sick patients

What are the advantages of using a biobank for endocrinal sample needs?

Setting up a biological collection and preparing samples for a clinical project


Saving time in the experimental phase

 

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Setting up a collection of biological samples

After a biopsy, or other procedure to retrieve a human sample, a sample may be retained, with the patient's consent, for research purposes.

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Storage of clinical samples

The samples, after collection, must be stored under certain conditions, depending on their type and shelf life, to allow for their viability.

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How is a endocrinal, metabolic or nutritional collection request made?

Collecting, receiving and sending biological samples of endocrinal, metabolic or nutritional diseases are regulated activities and must be declared and/or subject to authorization. The biobank or biological resource center assists external applicants in the structuring of their project and their administrative procedures.

Setting up a biological collection

The first step in setting up a sample collection is to identify the partner(s) with both access to patients with the disease of interest, and also the technical capacity to collect the type of biological samples required.

Biobanks will typically be able to respond individually to certain requests, and collectively to requests that require expertise or resources not available to them. This is particularly the case for specialized biobanks such as tumor banks, cell banks, serum banks, etc.

Since these are biological samples from patients, the request must be motivated, clear, and included in a proposal that can be shared with the biobank. The required information generally relates to the nature of the project in which the biological collection is to be built up, the number and types of clinical samples desired, the processing and preparation of the samples for analysis, etc. The information should be provided in a clear and concise manner.

The biobank can decide for or against the setting up of the project; the files are submitted to a scientific committee, which must give its approval before proceeding with the project. If the project continues, a feasibility study is carried out to determine whether the biobank has the technical capacity for the application. A financial estimate, as well as the drafting of a contract is carried out by the biobank in order to finalize the agreement between the parties. Finally, the biobank puts in place the internal operating procedure for collection, reception, storage and preparation of the biological resources until they are taken over.

Access a pre-existing collection - availability

Retroactive sample release is a transfer of biological material to another organization (public or private) as part of a joint research program (research partnership). This partnership must be formalized by a research collaboration agreement or contract that defines the framework of the joint research between the partners and the use that will be made of the biological resources. Applications must also be motivated and included in a project, which will be submitted to a scientific committee or to the clinical manager of the biological collection for validation. These requests may concern tumor or non-cancerous samples, as well as blood cells in the case of regular requests.

Types of providers

There are two major categories of biological resource centers:

University hospital structures

The majority of biobanks and BRCs are attached to a public hospital organization, which give them access to clinical physicians and allow them for biological collections from patients.

Service companies

Some private service companies may provide collections built up in the course of in-house projects or organize sample collections for clinical projects.

These two types of service providers differ from their public or private nature and their degree of specialization in a certain type of biological resources: cell bank, tumor bank, serum bank, etc.

Used technologies

Automatic DNA and RNA extractors

Conservation cold environment: freezers -20°C, -80°C and tank Liquid nitrogen -180°C

Computer system for managing anonymized data

Estimated rates for this type of service

Setting up a collection: €5,000 to €15,000

The price of a biological sample depends on the preparation required (slide, fresh, nucleic acid extracts), the original organ, the desired quantity and the clinical information associated with the patient; and can vary from approximately €200 to €2,000.