Blood disorders biological samples & experimental services

What are blood disorders?

Blood disorders are conditions that affect the production of blood or its components, such as red blood cells, white blood cells, platelets, and plasma. Examples of blood disorders include anemia, leukemia, blood clots, and bleeding disorders like hemophilia. These conditions can lead to health problems such as fatigue, infections, and difficulty with blood clotting.

Research on blood disorders has made significant progress in recent years. There have been significant developments in the treatment of blood disorders, such as improved bone marrow and stem cell transplantation techniques, new drugs for cancer, and gene therapies for genetic blood disorders. Likewise, advances in technology and genomics have led to the development of improved diagnostic tools for blood disorders,  such as high-throughput sequencing and imaging techniques.

What types of samples are used in blood disorder research?

In blood disorder research, several types of biological specimens are used to study the underlying mechanisms and diagnose the condition. The following are some of the most common types of samples used in blood disorder research:

Blood samples

Whole blood, plasma, and serum are the most common blood disorders samples used for research purposes. These samples can be used to measure levels of specific proteins, hormones, or markers associated with blood disorders.



Bone marrow samples

Bone marrow is the soft tissue inside bones where blood cells are produced. Bone marrow samples are collected for the diagnosis of blood disorders such as leukemia and lymphoma.



Peripheral blood stem cells

Peripheral blood stem cells are immature blood cells that can be harvested from a person's bloodstream and used for transplantation purposes.



Tissue samples

Tissue samples, such as biopsy specimens, can be used to study the effect of blood disorders on specific organs or tissues.



Saliva samples

Saliva samples can be used to study genetic changes associated with blood disorders.



These samples are collected through various methods, such as venipuncture, bone marrow aspiration, and biopsy procedures, and are analyzed in the laboratory to help diagnose and understand the underlying mechanisms of blood disorders.

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Available types of blood diseases biological samples

  • Tissues
    • Fresh tissues
    • Frozen tissues (OCT and FF)
    • FFPE tissues
    • Healthy tissues
  • Blood derivatives
    • Whole blood
    • PBMC
    • Plasma
    • Serum
    • Leukapheresis
  • Biofluids
    • Urine
    • Stool/Feces
    • Saliva
Our service identifies sample sources able to prepare and transfer a sample collection for any given project. Just ask our team to discuss your project!

Types of Collections

  • Retrospective: we can look into existing biobank collections 
  • Prospective: we can set up clinical collection specific to a given project

Experimental models used in blood disorder R&D

There are several experimental models used in blood disorder research and development, including:


Cell culture models: cell culture is a widely used experimental model in which cells are grown in a controlled environment outside the body. This allows for the study of the biology of blood cells, including their development and response to various treatments.

Animal models: in vivo models, such as mice and rats, are used to study the effects of blood disorders and to test new treatments. These models can be engineered to mimic specific blood disorders, such as hemophilia or sickle cell anemia.

Humanized mouse models:  humanized mouse models involve transplanting human hematopoietic stem cells into mice to create a mouse with a human-like immune system. This model is used to study the interactions between the immune system and blood cells in the context of blood disorders.


These experimental models allow researchers to gain a deeper understanding of the underlying mechanisms of blood disorders and to develop and test new treatments.

 

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Typical deliverables

  • Feasibility of availability of samples or experimental services
  • Regulatory aspects (transfer authorizations, export authorizations, ethics committee agreement)
  • Contracting
  • Samples shipment in appropriate conditions
  • Clinical data or results
  • Other services (i.e. Nucleic acid extraction, quality control)

 

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Get started with your blood disorder research request

Please answer the fields below to be contacted by our team of scientists

Our team will handle your blood disorders related R&D outsourcing from the beginning to the end

Perform a feasibility study by looking for existing samples already in collections & ready to be transferred


Set up a clinical biological collection and preparing contracts with sources


Assist the material transfer from the source to the lab, including treatments, QA or shipping, as needed

Some examples of blood disorders

The incidence of blood diseases varies depending on the specific type of blood disorder and the population being studied. Some blood disorders are more common than others, and their incidence may also vary by demographic factors such as age, gender, and ethnic background.
For example, anemia is a very common blood disorder, affecting a significant portion of the population. Sickle cell anemia, on the other hand, is a relatively rare blood disorder that primarily affects people of African descent. Leukemia is one of the most common cancers in children and young adults, while multiple myeloma is more common in older adults.
The incidence of blood disorders can also be influenced by environmental and lifestyle factors, such as exposure to toxins and pollutants, and can be affected by access to healthcare and early diagnosis and treatment.

 
Anemia is a condition in which there is a decrease in the number of red blood cells or hemoglobin, leading to a reduction in oxygen-carrying capacity.
 
Leukemia is a cancer of the blood and bone marrow, resulting in an abnormal production of white blood cells.
 
Hemophilia is a bleeding disorder caused by a deficiency in certain clotting factors, leading to prolonged bleeding after injury or surgery.

Sickle cell anemia is a genetic disorder in which red blood cells become crescent-shaped and can clog small blood vessels, leading to reduced blood flow and pain.