Gastrointestinal diseases refer to a group of illnesses that affect the digestive system, including the organs from the mouth to the anus such as the esophagus, stomach, small intestine, large intestine, liver, pancreas, and gallbladder.
Examples of common gastrointestinal diseases include peptic ulcer disease, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and hepatitis.
These conditions can cause symptoms such as abdominal pain, diarrhea, constipation, nausea, and vomiting.
Used to assess the presence of bacteria, viruses, or parasites, as well as to measure biomarkers that indicate gastrointestinal inflammation.
Obtained through endoscopy or laparoscopy procedures, used to examine the tissue and cells of the gastrointestinal tract for signs of inflammation or other changes.
Used to measure levels of certain hormones, cytokines, or other markers that indicate the presence of a gastrointestinal disorder.
Obtained by wiping the inside of the gut with a swab, used to assess the microflora and immune function in the gut.
used to measure levels of specific metabolic byproducts that may indicate the presence of a gastrointestinal disorder.
Experimental models are crucial tools used in gastrointestinal disorders research and development. Some of the most commonly used experimental models include:
Cell culture models: where cells from the gastrointestinal tract are grown in the laboratory and used to study cellular processes and responses to drugs or other treatments.
Animal models: where various species such as mice, rats, or pigs are used to simulate human gastrointestinal disorders and to test potential treatments.
Organoids models: where 3D cultures of cells from the gastrointestinal tract are grown in the laboratory and used to study organ function and disease.
Ex vivo models: where segments of the gastrointestinal tract are removed and maintained outside the body in a controlled environment, used to study the transport of nutrients, drug absorption, and motility.
Human tissue models: where human tissue samples are obtained from patients undergoing surgical procedures and used to study the molecular and cellular processes of gastrointestinal disorders.
These models provide valuable information and help to advance our understanding of gastrointestinal disorders, as well as to develop and test new treatments. However, it is important to note that these models have limitations, and results from animal or in vitro models may not always be directly applicable to human populations.
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Perform a feasibility study by looking for existing samples already in collections & ready to be transferred
Set up a clinical biological collection and preparing contracts with sources
Assist the material transfer from the source to the lab, including treatments, QA or shipping, as needed