en
Contact Us

Gastrointestinal disorders samples and R&D services

What are gastrointestinal diseases?

Gastrointestinal diseases refer to a group of illnesses that affect the digestive system, including the organs from the mouth to the anus such as the esophagus, stomach, small intestine, large intestine, liver, pancreas, and gallbladder.

Examples of common gastrointestinal diseases include peptic ulcer disease, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and hepatitis.

These conditions can cause symptoms such as abdominal pain, diarrhea, constipation, nausea, and vomiting. 

What types of samples are used in gastrointestinal disorder research?

In gastrointestinal disorder research, various types of samples can be collected and analyzed to understand the underlying causes and mechanisms of the disease, as well as to develop and evaluate diagnostic and therapeutic methods. Some of the most common types of samples used in gastrointestinal disorder research include:

Stool samples

Used to assess the presence of bacteria, viruses, or parasites, as well as to measure biomarkers that indicate gastrointestinal inflammation.



Biopsy samples

Obtained through endoscopy or laparoscopy procedures, used to examine the tissue and cells of the gastrointestinal tract for signs of inflammation or other changes.



Blood samples

Used to measure levels of certain hormones, cytokines, or other markers that indicate the presence of a gastrointestinal disorder.



Mucosal samples

Obtained by wiping the inside of the gut with a swab, used to assess the microflora and immune function in the gut.



Urine samples

used to measure levels of specific metabolic byproducts that may indicate the presence of a gastrointestinal disorder.



These samples can provide valuable information to help diagnose, monitor, and treat gastrointestinal disorders.

Gastrointestinal disorders samples

Available types of gastrointestinal diseases biological samples

  • Tissues
    • Fresh tissues
    • Frozen tissues (OCT and FF)
    • FFPE tissues
    • Healthy tissues
  • Blood derivatives
    • Whole blood
    • PBMC
    • Plasma
    • Serum
    • Leukapheresis
  • Biofluids
    • Urine
    • Stool/Feces
    • Saliva
    • Mucosal swabs
Our service identifies gastrointestinal disorder sample sources able to prepare and transfer a sample collection for any given project. Just ask our team to discuss your project!

Types of Collections

  • Retrospective: we can look into existing biobank collections 
  • Prospective: we can set up clinical collection specific to a given project

Experimental models used in gastrointestinal disorder R&D

Experimental models are crucial tools used in gastrointestinal disorders research and development. Some of the most commonly used experimental models include:

Cell culture models: where cells from the gastrointestinal tract are grown in the laboratory and used to study cellular processes and responses to drugs or other treatments.

Animal models: where various species such as mice, rats, or pigs are used to simulate human gastrointestinal disorders and to test potential treatments.

Organoids models:  where 3D cultures of cells from the gastrointestinal tract are grown in the laboratory and used to study organ function and disease.

Ex vivo models: where segments of the gastrointestinal tract are removed and maintained outside the body in a controlled environment, used to study the transport of nutrients, drug absorption, and motility.

Human tissue models:  where human tissue samples are obtained from patients undergoing surgical procedures and used to study the molecular and cellular processes of gastrointestinal disorders.

These models provide valuable information and help to advance our understanding of gastrointestinal disorders, as well as to develop and test new treatments. However, it is important to note that these models have limitations, and results from animal or in vitro models may not always be directly applicable to human populations.

 

R&D mecanism Labtoo 200-1

Typical deliverables

  • Feasibility of availability of samples or experimental services
  • Regulatory aspects (transfer authorizations, export authorizations, ethics committee agreement)
  • Contracting
  • Samples shipment in appropriate conditions
  • Clinical data or results
  • Other services (i.e. Nucleic acid extraction, quality control)

 

Capture d’écran 2020-10-16 à 10.57.43

Get started with your gastrointestinal diseases research request

Please answer the fields below to be contacted by our team of scientists

Our team will handle your respiratory disorders R&D procurement from the beginning to the end

Perform a feasibility study by looking for existing samples already in collections & ready to be transferred

Set up a clinical biological collection and preparing contracts with sources

Assist the material transfer from the source to the lab, including treatments, QA or shipping, as needed

Some examples of gastrointestinal disorders

Functional gastrointestinal disorders (FGIDs) are very common and affect a very large part of the population. Although numbers of prevalence have been historically difficult to find, a global survey from the Rome Foundation established that overall, 49% of women and 36.6% of men met the criteria for at least one functional gastrointestinal disorder (FGID).
Gastrointestinal disorders include the following pathologies: gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), ulcerative colitis, Crohn's disease, gastroparesis, peptic ulcer disease, celiac disease, liver cirrhosis, hepatitis, gallstones, and pancreatitis.
 
 
Gastroesophageal Reflux Disease (GERD) is a chronic digestive disorder that occurs when the acid and contents from the stomach move back into the esophagus. This causes irritation and inflammation of the esophagus lining, leading to symptoms such as heartburn, chest pain, cough, hoarseness, and difficulty swallowing. GERD is often treated with lifestyle changes, medications, and sometimes surgery.
 
Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain, discomfort, bloating, and altered bowel habits (such as diarrhea or constipation) in the absence of any organic cause. The exact cause of IBS is not known, but it is thought to be related to a combination of factors such as altered gut motility, sensitivity, and changes in gut bacteria. IBS is usually managed through a combination of dietary changes, medication, and stress management techniques.
 
Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory disorders that affect the digestive tract, including the small intestine and colon. The two main types of IBD are Crohn's disease and ulcerative colitis. IBD causes inflammation and ulceration of the intestinal lining, leading to symptoms such as abdominal pain, diarrhea, weight loss, and rectal bleeding. The exact cause of IBD is unknown, but it is believed to be related to a combination of genetic, environmental, and immune system factors. IBD is usually treated with medication, dietary changes, and in severe cases, surgery.