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Respiratory disorders samples and experimental services

What are respiratory diseases?

Respiratory diseases refer to a group of illnesses that affect the respiratory system, including the lungs, bronchi, trachea, and alveoli. These diseases can range from mild, such as the common cold, to severe, such as pneumonia and tuberculosis.

Examples of respiratory diseases include asthma, bronchitis, COPD, cystic fibrosis, lung cancer, and COVID-19 (caused by the SARS-CoV-2 virus).

What types of samples are used in respiratory disorder research?

The type of sample used depends on the specific research question being studied and the stage of the disease being evaluated. In respiratory disorder research, various types of respiratory biological samples can be used, including:

Mucus samples

Mucus and other material coughed up from the lungs, can be analyzed for the presence of bacteria, viruses, or other pathogens.



Bronchoalveolar Lavage (BAL) fluid

This is a sample of fluid taken from the lungs through a bronchoscope and can be used to assess lung function and the presence of inflammation or infection.



Blood samples

Blood can be analyzed for biomarkers associated with respiratory disorders, such as inflammation, oxidative stress, or immune responses.



Nasal swab samples

Samples taken from the nose or throat can be used to detect respiratory viruses or other pathogens.


Tissue samples

In some cases, small tissue samples from the lung can be collected through a biopsy procedure and analyzed for evidence of disease or infection.

Samples blood Labtoo 200-1

Available types of respiratory diseases biological samples

  • Tissues
    • Fresh tissues
    • Frozen tissues (OCT and FF)
    • FFPE tissues
    • Healthy tissues
  • Blood derivatives
    • Whole blood
    • PBMC
    • Plasma
    • Serum
    • Leukapheresis
  • Biofluids
    • Nasal swabs
    • Respiratory tract swabs
    • Urine
    • Stool/Feces
    • Saliva
Our service identifies sample sources able to prepare and transfer a sample collection for any given project. Just ask our team to discuss your project!

Types of Collections

  • Retrospective: we can look into existing biobank collections 
  • Prospective: we can set up clinical collection specific to a given project

What Labtoo can provide:

  • Feasibility of availability of samples or experimental services
  • Regulatory aspects (transfer authorizations, export authorizations, ethics committee agreement)
  • Contracting
  • Samples shipment in appropriate conditions
  • Clinical data or results
  • Other services (i.e. Nucleic acid extraction, quality control)

 

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Experimental models used in respiratory disorder R&D

There are several experimental models used in respiratory disorder research and development, including:

Cell culture models: utilizing human or animal cells in vitro to study cellular processes and interactions.

Animal models: using animals such as mice, rats, and rabbits to study the physiological and pathological effects of respiratory disorders.

Organoids models:  three-dimensional structures grown from stem cells or other cell types to resemble organs and allow for the study of cellular interactions.

Ex vivo models: utilizing human tissues obtained from biopsy or surgical specimens to study the molecular and cellular mechanisms of respiratory disorders.

Patient-derived xenografts (PDXs): using human tumor tissue implanted into immunocompromised mice to study the effects of the disease in a living organism.

Microfluidic models: utilizing microfluidic chips to recreate the complex fluid dynamics of the respiratory system in a controlled environment.

In silico models: using computer simulations to study the physiological and pathological processes of respiratory disorders.

These models are used to study various aspects of respiratory disorders, including pathogenesis, drug efficacy, and disease progression.

R&D mecanism Labtoo 200-1

Our team will handle your respiratory disorders R&D procurement from the beginning to the end

Perform a feasibility study by looking for existing samples already in collections & ready to be transferred

Set up a clinical biological collection and preparing contracts with sources

Assist the material transfer from the source to the lab, including treatments, QA or shipping, as needed

Some examples of respiratory disorders and prevalence

Respiratory disorders and diseases are very common and affect a very large part of the population. Respiratory disorders include the following pathologies: asthma, chronic obstructive pulmonary disease (COPD), bronchitis, pneumonia, tuberculosis (TB), bronchiectasis, lung cancer, sleep apnea, cystic fibrosis, interstitial lung disease, and pulmonary embolism.
 
The prevalence of respiratory diseases varies depending on the specific condition and the population being studied. However, according to the World Health Organization (WHO), as of 2021, around 339 million people globally have asthma. WHO estimates that COPD affects around 384 million people globally, and lung cancer is one of the leading causes of cancer-related deaths worldwide. The American Lung Association reports that in 2021, approximately 228,820 new cases of lung cancer were diagnosed in the United States and about 135,720 people died from the disease.

These figures demonstrate the high prevalence of respiratory diseases and the significant impact they can have on people's health and well-being. 
 
 
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that makes it difficult to breathe. It's caused by damage to the lungs, usually from smoking and characterized by airflow blockage that is not fully reversible. Symptoms include coughing, wheezing, shortness of breath, and chest tightness. There is no cure for COPD, but it can be managed with medication, lifestyle changes, and in severe cases, oxygen therapy.
 
Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to symptoms such as wheezing, coughing, chest tightness, and difficulty breathing. It is often triggered by environmental factors such as allergens, irritants, and exercise, and can be managed through a combination of lifestyle modifications, medications, and avoiding triggers.
 
Inflammatory Bowel Disease (IBD) is a group of chronic digestive disorders characterized by inflammation in the gastrointestinal tract. The two main types of IBD are Crohn's disease and ulcerative colitis. Symptoms of IBD include diarrhea, abdominal pain, weight loss, and rectal bleeding. The exact cause of IBD is unknown, but it is thought to involve a combination of genetic and environmental factors. Treatment for IBD typically involves medications to reduce inflammation and manage symptoms, as well as lifestyle modifications to improve overall health and wellbeing. In some cases, surgery may be necessary.