Drug Discovery & Development Services

The development of new drugs requires the integration of a large number of experiments and validation.
Screening can be useful when a mechanism of action or pathology model is already mastered. Proof of concept can be provided for identified candidates using biochemical, in silico, in vitro, ex vivo, or in vivo models.
The molecules can be tested for their pharmacokinetic and pharmacological behavior in small animals (ADME). Optimizations can be performed by chemical modification (small molecule) or mutations for biomolecules.

1 - Cell culture-1

ADME

Drug metabolism assays
Toxicology assays
Hemolytic effect evaluation
42 - Monoclonal Antibody

Biochemical models

Immune checkpoints
FRET & HTRF assays
15 - Drug Discovery

Galenic formulation

Feasibility study
Characterisation & production
44 - Phage Display-3

HCS & HTC screening

Cell culture screening plate preparation
HTS & HCS - Study design & tests
HCS - Antiviral screening
Biomarkers development
167 - Analyse-Voie-Signa-1

In vitro models

Immune checkpoints
Electrophysiology - patch clamp & MEA
Functional cell assays
Cytotoxicity
Immune modulation test
3a - Models-1

In vivo models

Animal models
PDX - Efficacy study
Physiological assays
Live imaging on animal models
Cognitive, behavioral & psychiatric tests
Pharmacokinetics & pharmacodynamics
Toxicity
Target validation & efficacy
Ecotoxicity & aquatic toxicity assay
Combination therapy anti-PD1 or anti-CTLA4
208 - Reponse-immunitaire-1

Innovative therapy

Advanced therapeutics medicinal
176 - Anticorps-Recombinant

In silico

HTS & HCS screening modeling
Antibody cross-reactivity
Alternative to a specific antibody
Identification of epitopes
Target of an antibody
17 - Criblage-2

Molecules

Custom molecule synthesis
Compound library
Radiolabelling of molecules
favicon large-1

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