In vitro metabolism assays are a part of the ADME (Absorption, Distribution, Metabolism, Elimination) tests and are used to evaluate the fate of pharmaceutical compounds, usually drugs, in the liver (hepatocytes) and extrahepatic tissues, such as intestines, kidneys, etc.
The tests will identify metabolites and their structure, identify activated enzyme pathways, and measure in vitro degradation by screening.
Materials to provide
Samples in sufficient amounts.
Description of the samples.
Further details on the project may be requested.
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Typical deliverables
Metabolite half-life determination.
Metabolic soft-spots identification.
Enzymatic pathways determination.
Metabolite structure determination.
Kinetic parameters.
Study following the specifications validated with the Expert.
Get started with your Drug metabolism assay
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