Generation of de novo protein specific ligands
This technology allows the de novo generation of artificial protein ligands to identify a target of interest. The use of protein ligands is a stable and simple alternative to the production of monoclonal antibodies that do not present a risk of post-translational modifications. The methodology combines ribosome display, next-generation sequencing, and bioinformatics technologies. The production of ligands in E. coli is reproducible, inexpensive, and GMP-compatible.
Materials to provide
- Sample sequence if known
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- Determination of binder with high affinity against the target of interest
- Identification of binder sequences
- Study following the specifications validated with the Expert
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