In silico determination of epitopes recognized by an antibody
The structure of the antibody can be modeled so only the sequences are needed. The structure of the target has to be solved to ensure the best efficiency of the prediction. The number of times each amino acid is predicted to be in the epitope among the 30 best solutions is calculated and peptides are designed among these amino acids. For this reason, linear as well as conformational epitopes can be considered for validations. The peptides are then used to performed cutting-edge techniques of protein-protein interactions.
Materials to provide
- Antibody sequence
Further details on the project may be requested.
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- PDB files of the 30 top-ranked antibody-antigen complexes structures
- Peptides sequences
- Raw and analyzed experimental data
- Complete report with validation methods
- Study following the specifications validated with the Expert
Get started with your in silico epitope recognition project
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