Antibody humanization by CDR-grafting

monoclonal ab 300x225

Service description

  • The humanization of antibodies reduces the potential immunogenicity of a mouse parental antibody in a human context and increases its stability.
  • These experiments include the integration of variable regions (CDRs) of a "parental" monoclonal antibody into a human immunoglobulin structure and optimizing this integration and then expressing the antibodies.
  • In this service, it is possible to select different options such as sequence optimization or chimeric antibody expression.

Materials to provide

  • Hybridomas expressing the antibodies to humanize.
  • Information regarding the hybridomas.

  • Further details on the project may be requested.
  • You will be able to exchange directly with the experts after filling in the form below.

Typical deliverables

  • Antibody sequencing.
  • Development of a chimeric antibody.
  • Optimisation of sequences.
  • Variants production and tests against the chimeric version.
  • Production of antibodies best candidates in the specified amount.
  • Quality control of the production.
  • Antibody expression vectors sequenced and provided in the desired format.
  • Study following the specifications validated with the Expert.
Capture d’écran 2020-10-16 à 10.57.43

Get started with your antibody humanization

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