In silico identification of antibody cross-reactivity
Based on a technique that analyses the similarity of sequences and the structure of CDR (Complementarity Determining Region) of known antibodies and a new antibody. It allows identify possible cross-reactions of an antibody with other proteins ("off target"). These reactions may be positive or negative, but their knowledge is essential before the start of a clinical trial.
Materials to provide
- Antibody sequence
Further details on the project may be requested.
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- PDB files of the 30 top-ranked antibody-antigen complexes structures
- Peptides sequences
- Raw and analyzed experimental data
- Complete report with validation methods
- Study following the specifications validated with the Expert
Get started with your in silico identification of antibody cross-reactivity project
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