In silico identification of antibody cross-reactivity

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Service description

  • Based on a technique that analyses the similarity of sequences and the structure of CDR (Complementarity Determining Region) of known antibodies and a new antibody.
  • It allows the identification of possible cross-reactions of an antibody with other proteins ("off-target").
  • These reactions may be positive or negative, but their knowledge is essential before the start of a clinical trial.

Materials to provide

  • Antibody sequence.

  • Further details on the project may be requested.
  • You will be able to exchange directly with the experts after filling in the form below.

Typical deliverables

  • PDB files of the 30 top-ranked antibody-antigen complexes structures.
  • Peptides sequences.
  • Raw and analyzed experimental data.
  • Complete the report with validation methods.
  • Study following the specifications validated with the Expert.
Capture d’écran 2020-10-16 à 10.57.43

Get started with your in silico identification of antibody cross-reactivity project

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