Immune checkpoints biochemical assays

monoclonal ab 300x225

Service description

  • To escape destruction by the immune system, tumor cells can modulate the expression of proteins involved in immune checkpoints.
  • For example, programmed cell death protein 1 (PD1) is an immune checkpoint receptor that regulates the T cell response.
  • Its ligand, programmed death ligand 1 (PD-L1), is usually overexpressed on the surface of tumor cells.
  • When PD1 is bound to PD-L1, the T-cell response is suppressed, contributing to the immune resistance of tumors.
  • Checkpoint inhibitors that block the formation of the PD1/PD-L1 complex are of considerable interest in cancer immunotherapy, and thus these proteins are a subject of great interest in immuno-oncology research.
  • In this assay, several biochemical tests can be chosen to measure the inhibition of these checkpoints by molecules.

Materials to provide

  • Compounds to test in sufficient amounts.
  • Information regarding the compounds to test.

  • Further details on the project may be requested.
  • You will be able to exchange directly with the experts after filling in the form below.

Typical deliverables

  • Setting up the test.
  • Tests of inhibition.
  • Read-out of the results.
  • Study following the specifications validated with the Expert.
Capture d’écran 2020-10-16 à 10.57.43

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