To escape destruction by the immune system, tumor cells can modulate the expression of proteins involved in immune checkpoints.
For example, programmed cell death protein 1 (PD1) is an immune checkpoint receptor that regulates the T cell response.
Its ligand, programmed death ligand 1 (PD-L1), is usually overexpressed on the surface of tumor cells.
When PD1 is bound to PD-L1, the T-cell response is suppressed, contributing to the immune resistance of tumors.
Checkpoint inhibitors that block the formation of the PD1/PD-L1 complex are of considerable interest in cancer immunotherapy, and thus these proteins are a subject of great interest in immuno-oncology research.
In this assay, several biochemical tests can be chosen to measure the inhibition of these checkpoints by molecules.
Materials to provide
Compounds to test in sufficient amounts.
Information regarding the compounds to test.
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Setting up the test.
Tests of inhibition.
Read-out of the results.
Study following the specifications validated with the Expert.
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