The use ofin vitro testson isolated human cellsandin vivo tests on animal models has limitations: the failure to take into account the tissue complexity for isolated cells and the failure to guarantee the possibility of extrapolating data obtained from animals to humans.
For this reason, the use of human explants of the stomach, intestine, skin, or liver, provides a way to test the compounds on a complex human model closer to the physiological reality than isolated cells.
Several tests are available: viability, barrier function for intestinal explants, absorption and metabolism function, immune function, and infection by pathogenic bacteria for skin and intestinal explants.
Materials to provide
Products to be tested.
Conditions of testing.
Further details on the project may be requested.
You will be able to exchange directly with the experts after filling in the form below.
Typical deliverables
Explants.
Assay set up.
Study following the specifications validated with the Expert.
Experimentation as required.
Analysis and report.
Get started with your intestinal and hepatic explants testing project
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