In silico identification of antibody cross-reactivity

176 - Anticorps-Recombinant

Service description

Based on a technique that analyses the similarity of sequences and the structure of CDR (Complementarity Determining Region) of known antibodies and a new antibody. It allows identify possible cross-reactions of an antibody with other proteins ("off target"). These reactions may be positive or negative, but their knowledge is essential before the start of a clinical trial.

Materials to provide

  • Antibody sequence

    Further details on the project may be requested.

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Typical deliverables

  • PDB files of the 30 top-ranked antibody-antigen complexes structures
  • Peptides sequences
  • Raw and analyzed experimental data
  • Complete report with validation methods
  • Study following the specifications validated with the Expert

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