Target identification and validation characterize the role of a protein or pathway of interest and provide selection arguments to define the required properties of the compounds to be screened.
The main strategies involved in target validation are gene knock-out studies, knock-down by antisense RNA or RNA interference, and direct inhibition of proteins by small molecules, peptides, antibodies, aptamers, or any other class of inhibitors.
Materials to provide
Samples to test.
Further details on the project may be requested.
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Assessment of specific processes.
General toxicity assessment of drug screening.
Study following the specifications validated with the Expert.
Get started with your in vivo target validation project
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